The 28th Combat Support Hospital was constituted on May 25, 1943 and activated in June of 1943. It was deployed in the Pacific theater of World War II. During the war, the 28th Combat Support Hospital was awarded the China Defense and Offense Campaign Battle Streamers. This award gave them the nickname "China Dragons."
During December, 1945, towards the end of World War II, the 28th Combat Support Hospital was inactivated. It was later reactivated on July 25, 1972 as a Medical Unit Self-Contained Transportable in Fort Bragg, North Carolina. Between August 1990-1991, it was deployed in Asia to support Operation Dessert Storm and Desert Shield. In August, 1992, it was sent back to the United States to Florida to help those injured after Hurricane Andrew. It later returned to southwestern Asia during Operation Iraqi Freedom where it set up a 44 bed hospital to support the 3rd and 101st Infantry during the capture of Baghdad.
The 28th Combat Support Hospital was once again deployed in Iraq in September, 2006. They were stationed there for 15 months and received a Meritorious Unit Commendation, it's third so far. On October 29, 2009, The 28th Combat Support Hospital once again deployed in Iraq and spread into four separate locations. It served as the Medical Task Force Headquarters and provided health care. It was responsible for the care provided for the southern Iraq Joint Operations Area.